| 敏感性 | 对光敏感 |
| 溶解性 | Soluble in DMSO (5 mg/ml), and water (210 mg/L). |
| 存贮条件 | 储存温度-20°C |
| 应用 | An RNA polymerase inhibitor and suppressor of tumor cell-induced angiogenesis |
| 产品介绍 | Thiolutin is an RNA polymerase inhibitor, and a sulfur-based microbial antibiotic generated by Streptomyces sp. The compound has been shown to inhibit transcription in Saccharomyces cerevisiae and mRNA degradation. Thiolutin inhibits the adhesion of endothelial cells, including adhesion of human umbilical vein endothelial cells (HUVECs) to vitronectin, and restricts tumor cell-induced angiogenesis. Studies have reported that Thiolutin is an effective inducer of HSP 27 (heat shock protein 27; Hsp27) phosphorylation. Research shows that in the presence of Thiolutin, the interaction between Hsp27 and nestin is disrupted, which results in the breakdown of nestin filaments. |
| 别名 | Thiolutin;Farcinicin; N-(4,5-Dihydro-4-methyl-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl); Propiopyvothine;Acetopyrrothine |
硫藤黄素
Thiolutin （订货以英文为准）
编号：T102393
CAS号：87-11-6
分子式：C8H8N2O2S2
分子量：228.29
| 产品名称 | Thiolutin |
| 中文名称 | 硫藤黄素 |
| CAS号 | 87-11-6 |
| 分子式（M.F.） | C8H8N2O2S2 |
| 分子量（M.W.） | 228.29 |
| 储存条件 | -20°C储存 |
| Merck Index | 8198 |
| 标识符号 | https://www.aladdin-e.com/images/ghs/ghs08.jpg |
| 信号词 | Danger |
| 危害声明 | H360 |
| 警示性声明 | P201,P308+P313 |
| 个人防护设备 | Eyeshields,full-face particle respirator type N100 (US),Gloves,respirator cartridge type N100 (US),type P1 (EN143) respirator filter,type P3 (EN 143) respirator cartridges |
| RTECS | XZ4250000 |
| WGK德国 | 3 |
| 风险声明 (欧洲) | 61 |
| 安全声明（欧洲） | 53,22,45 |
| 危害码（欧洲） | T |
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