| 溶解性 | DMSO 25 mg/mL Water <1 mg/mL Ethanol <1 mg/mL |
| 备注 | GW441756 is a potent, selective inhibitor of TrkA with IC50 of 2 nM, with very little activity to c-Raf1 and CDK2. |
| 生化机理 | Description:IC50 Value: 2nM [1]GW 441756 is a specific Tropomyosin-related kinase A (TrkA) inhibitor with an IC50 value of 2 nM.in vitro: GW441756 specifically blocked TrkA-induced cell death in a dose-dependent manner, but there was no effect in uninduced cells. TrkA ability to induce γH2AX production was significantly downregulated by both K-252a and GW441756 in the absence of DNA damage inducer. In addition, it was also suppressed by K-252a during DNA damage by doxorubicin treatment, but not by GW441756 [2].in vivo: N/AClinical trial: N/A |
| 别名 | 2H-Pyrrolo[3,2-b]pyridin-2-one, 1,3-dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-;2H-Pyrrolo[3,2-b]pyridin-2-one, 1,3-dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]- |
GW441756,TrKA受体酪氨酸激酶抑制剂
GW441756 （订货以英文为准）
编号：G129825
CAS号：504433-23-2
分子式：C17H13N3O
分子量：275.30
| 产品名称 | GW441756 |
| 中文名称 | GW441756,TrKA受体酪氨酸激酶抑制剂 |
| CAS号 | 504433-23-2 |
| 分子式（M.F.） | C17H13N3O |
| 分子量（M.W.） | 275.30 |
| 储存条件 | -20°C储存 |
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