| 熔点 | 153°C |
| 旋光率 | 281° (C=0.4,Acetone) |
| 存贮条件 | 储存温度 2-8°C |
| 密度 | 1.1300 |
| 应用 | 3-羟基-3-甲基戊二酰-CoA还原酶（3-hydroxy-3-methylglutaryl-CoA reductase）、HMG-CoA还原酶（HMG-CoA reductase）抑制剂。 |
| 生化机理 | Mevastatin (Compactin) inhibits HMGCR (HMG-CoA reductase) (Ki for acid form is 1 nM) which in turn inhibits isoprenoid biosynthesis and therefore blocks protein isoprenylation and reduces plasma cholesterol levels in humans. Mevastatin induces apoptosis, arrests cancer cells in G1 phase and downregulates cdk 2, 4, and 6, cyclin D1 and E1, p21 and p27. Mevastatin suppresses TNF-induced NF-κB activation (IC50 = ~17 ?M), which potentiates apoptosis in human myeloid leukemia cells and thus, may be useful in treating cancer. |
| 别名 | 美伐他汀;美池他汀;康帕丁;康百汀;CompactinML-236B |
美伐他汀
Mevastatin （订货以英文为准）
编号：M107870
CAS号：73573-88-3
分子式：C23H34O5
分子量：390.51
| 产品名称 | Mevastatin |
| 中文名称 | 美伐他汀 |
| CAS号 | 73573-88-3 |
| MDL编码 | MFCD05662341 |
| 分子式（M.F.） | C23H34O5 |
| 分子量（M.W.） | 390.51 |
| 储存条件 | 2-8°C储存 |
| 个人防护设备 | Eyeshields,Gloves,half-mask respirator (EU),half-mask respirator (US),multi-purpose combination respirator cartridge (US) |
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