| 熔点 | 177-180 °C |
| 溶解性 | Soluble in DMSO (11 mg/ml at 25 °C), water (<1 mg/ml at 25 °C), ethanol (<1 mg/ml at 25 °C), and 0.5% methylcellulose/0.2% Tween 80 (30 mg/ml at 25 °C). |
| 存贮条件 | 储存温度-20°C |
| 应用 | A PDK1 inhibitor and inducer of caspase and p53-independent apoptosis. |
| 产品介绍 | OSU-03012 (AR-12)是一种有效的重组PDK-1抑制剂，IC50为5 μM，比OSU-02067作用效果高2倍。 |
| 备注 | OSU-03012 is a potent inhibitor of recombinant PDK-1 with IC50 of 5 μM and 2-fold increase in potency over OSU-02067. |
| 生化机理 | OSU 03012 is a potent inhibitor of PDK1 (IC50 = 5 μM). OSU 03012 causes a dose-dependent induction of cell death regardless of the presence or absence of mutated p53. Studies have shown that upon treatment of cells with OSU 03012 there is an accumulation of reactive oxygen species (ROS) in the cell, which may contribute to cell death through oxidative damage. Exposure to ionizing radiation following treatment with OSU 03012 causes an increase in cell death, which is also caspase-independent. |
| 别名 | 2-氨基-N-[4-[5-(2-菲基)-3-(三氟甲基)-1H-吡唑-1-基]苯基]乙酰胺;N/AAR-12; OSU03012; OSU 03012;2-Amino-N-[4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]acetamide |
OSU-03012 (AR-12),PDPK1（PDK1）抑制剂
OSU-03012 (AR-12) （订货以英文为准）
编号：O126958
CAS号：742112-33-0
分子式：C26H19F3N4O
分子量：460.45
| 产品名称 | OSU-03012 (AR-12) |
| 中文名称 | OSU-03012 (AR-12),PDPK1（PDK1）抑制剂 |
| CAS号 | 742112-33-0 |
| 分子式（M.F.） | C26H19F3N4O |
| 分子量（M.W.） | 460.45 |
| 储存条件 | -20°C储存 |
| 个人防护设备 | Eyeshields， Gloves， type N95 (US)， type P1 (EN143) respirator filter |
| WGK德国 | 3 |
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