| 溶解性 | DMSO 42 mg/mL Water <1 mg/mL Ethanol <1 mg/mL |
| 存贮条件 | 储存温度-20°C |
| 产品介绍 | Milrinone |
| 备注 | Milrinone is a potent and selective phosphodiesterase 3 inhibitor with an IC50 of 0.42 μM for the inhibition of FIII PDE. |
| 生化机理 | Description:IC50 Value: 2mM( inhibiting human platelet aggregation) [3]Milrinone is a phosphodiesterase III inhibitor that increases intracellular cyclic adenosine monophosphate resulting in improved ventricular function and vasodilation.in vitro: Milrinone inhibited PDE4 in addition to PDE3 activity. In isolated rabbit cardiomyocytes, milrinone (>10 microM) caused greater elevations in intracellular cAMP and calcium than cilostazol [1]. cilostazol and milrinone were equally effective in inhibiting human platelet aggregation with a median inhibitory concentration (IC50) of 0.9 and 2 microM, respectively. In rabbit ventricular myocytes, however, cilostazol elevated cAMP levels to a significantly lesser extent (p < 0.05 vs. milrinone) [3].in vivo: Increased blood concentrations of milrinone were associated with increased inhibition of ADP and AA-induced platelet activation (P < 0.0001). Milrinone at a blood concentration of 300 ng/mL mark |
| 别名 | 米力农;米利酮;甲腈吡啶酮;甲腈吡酮;甲腈联吡啶酮;2-甲基-6-氧-1,6-二氢-[3,4'双吡啶]-5-甲腈;3-Cyano-6-methyl-5-(4-pyridyl)-2-pyridone;6-Methyl-5-(4-pyridyl)-2-pyridone-3-carbonitrile;1,6-Dihydro-2-methyl-6-oxo-(3,4′-bipyridine)-5-carbonitrile;Corotrope;Milrila |
米利酮
Milrinone （订货以英文为准）
编号：M129587
CAS号：78415-72-2
分子式：C12H9N3O
分子量：211.22
| 产品名称 | Milrinone |
| 中文名称 | 米利酮 |
| CAS号 | 78415-72-2 |
| 分子式（M.F.） | C12H9N3O |
| 分子量（M.W.） | 211.22 |
| 储存条件 | 低温运输 |
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