| 熔点 | 89.0-93.0°C |
| 存贮条件 | 储存温度-20°C |
| 应用 | 带有影响细胞DNA的抗肿瘤药物。洛莫司汀诱导A2870细胞p53的表达 |
| 生化机理 | Description:IC50 Value: N/ALomustine (or "CCNU")(Marketed under the name CeeNU in US) is an alkylating nitrosourea compound used in chemotherapy.in vitro: vincristine and lomustine trigger apoptosis in all these cells through the mitochondrial pathway via decrease in the level of the anti-apoptosis proteins Bcl-2 and Bcl-xl, respectively [1]. There was significant correlation between the level of cadherin-associated protein beta 1 (CTNNB1) and Aurora kinase A (STK15) proteins and neurotrophic tyrosine kinase receptor type 3 (TRKC) mRNA and the proportion of apoptosis induced by vincristine, the combination of both drugs, and lomustine, respectively [4].in vivo: IC50 values for CCNU admixed and encapsulated with lipid vesicles were 18+/-4.9 and 14.0+/-2.2 microM, respectively, compared to 83+/-11.0 microM for free CCNU in rats [2]. Eight of the 19 dogs (42%) had a measurable response to CCNU. One dog had a durable complete response for |
| 别名 | 1-(2-氯乙基)-3-环己基-1-亚硝基脲;1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea |
洛莫司汀
Lomustine （订货以英文为准）
编号：L123247
CAS号：13010-47-4
分子式：C9H16N3O2CL
分子量：233.70
| 产品名称 | Lomustine |
| 中文名称 | 洛莫司汀 |
| CAS号 | 13010-47-4 |
| 分子式（M.F.） | C9H16N3O2CL |
| 分子量（M.W.） | 233.70 |
| 储存条件 | -20°C储存 |
| Reaxys-RN | 3572117 |
| Merck Index | 86 |
| 标识符号 | https://www.aladdin-e.com/images/ghs/ghs07.jpg |
| 信号词 | Warning |
| 危害声明 | H315,H319,H335 |
| 警示性声明 | P261,P305+P351+P338 |
| 个人防护设备 | dust mask type N95 (US),Eyeshields,Gloves |
| RTECS | FZ9680000 |
| WGK德国 | 3 |
| 风险声明 (欧洲) | R36/37/38 |
| 安全声明（欧洲） | S26;S36 |
| 危害码（欧洲） | Xi |
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