| 溶解性 | DMSO |
| 存贮条件 | 储存温度-20°C |
| 产品介绍 | SR3335 (ML-176)能特异地与RORα结合，而不与其它的ROR结合，是RORα部分反向激动剂 |
| 生化机理 | SR3335 (ML-176), a selective RORα synthetic ligand, directly binds to RORα, but not other RORs, and functions as a selective partial inverse agonist of RORα in cell-based assays. Furthermore, SR3335 suppresses the expression of endogenous RORα target genes in HepG2 involved in hepatic gluconeogenesis including glucose-6-phosphatase and phosphoenolpyruvate carboxykinase. The first selective synthetic RORα inverse agonists may hold utility for suppression of elevated hepatic glucose production in type 2 diabetics. |
| 别名 | ML-176;SR 3335;SR-3335;ML176;ML 176;N-[4-[2,2,2-三氟-1-羟基-1-(三氟甲基)乙基]苯基]-2-噻吩磺酰胺;ML-176;SR 3335;SR-3335;ML176;ML 176;N-[4-[2,2,2-Trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-2-thiophenesulfonamide |
SR3335,RORα 反向激动剂
SR3335 （订货以英文为准）
编号：S125917
CAS号：293753-05-6
分子式：C13H9F6NO3S2
分子量：405.34
| 产品名称 | SR3335 |
| 中文名称 | SR3335,RORα 反向激动剂 |
| CAS号 | 293753-05-6 |
| 分子式（M.F.） | C13H9F6NO3S2 |
| 分子量（M.W.） | 405.34 |
| 储存条件 | -20°C储存 |
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