| 别名 | ;["5-Phenylmeldrum's Acid"] |
2,2-二甲基-5-苯基-1,3-二氧杂环己烷-4,6-二酮
2,2-Dimethyl-5-phenyl-1,3-dioxane-4,6-dione （订货以英文为准）
编号：D154128
CAS号：15231-78-4
分子式：C12H12O4
分子量：220.22
| 产品名称 | 2,2-Dimethyl-5-phenyl-1,3-dioxane-4,6-dione |
| 中文名称 | 2,2-二甲基-5-苯基-1,3-二氧杂环己烷-4,6-二酮 |
| CAS号 | 15231-78-4 |
| MDL编码 | D154128 |
| 分子式（M.F.） | C12H12O4 |
| 分子量（M.W.） | 220.22 |
| Reaxys-RN | 166017 |
技术规格
| Background: | The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels, and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor. In mouse, deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium. Multiple alternatively spliced variants, encoding the same protein, have been identified. The human genome contains five pseudogenes related to this gene, at least one of which is transcribed. |
| Applications: | WB |
| Name of antibody: | FKBP1A |
| Immunogen: | Fusion protein of human FKBP1A |
| Full name: | FK506 binding protein 1A, 12kDa |
| Synonyms： | FKBP1; PKC12; PKCI2; FKBP12; PPIASE; FKBP-12; FKBP-1A |
| SwissProt: | P62942 |
| WB Predicted band size: | 12 kDa |
| WB Positive control: | Mouse cerebellum tissue |
| WB Recommended dilution: | 500-2000 |
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