| 熔点 | 216°C |
| 敏感性 | 对光和湿度和热敏感 |
| 溶解性 | 溶于水、DMSO、四氢呋喃和醇，不溶于丙酮、苯、氯仿、乙醚。水中溶解度: 10 mg/mL, 水溶液为橙红色透明溶液。, |
| 存贮条件 | 储存温度：2-8°C |
| 应用 | 抗肿瘤抗生素，在心脏线粒体DNA方面有阿霉素的效果。反相转录酶和RNA聚合酶的抑制剂，免疫抑制剂；可插入DNA链中。临床上是癌症化疗剂、主要用于急、慢性白血病、恶性淋巴瘤。 |
| 产品介绍 | Doxorubicin (Adriamycin)是一种抗生素类试剂，抑制DNA拓扑异构酶II，且诱导DNA损伤和凋亡。 |
| 合法信息 | Adriamycin is a registered trademark of RDF Pharmacia & Upjohn S.P.A. |
| 生化机理 | Doxorubicin hydrochloride is a DNA intercalator and powerful cytotoxic agent. Once it associates with the DNA groove, a covalent linkage forms between a DNA base and the pendant sugar of the small molecule. The intercalation into DNA blocks the replication of DNA by blocking Topo II (Topoisomerase II) This general mechanism gives it efficacy in a wide range of different cell types. Additionally, the expression of the oncogenes c-Myc and c-Jun is also down regulated by the chemical and a significant correlation was reported between the level of expression of these genes and the degree of cell growth inhibition conferred by Doxorubicin. Doxorubicin hydrochloride is an inhibitor of AMPK, TERT and POLR. |
| 别名 | 盐酸多柔比星，羟基柔红霉素盐酸盐，DOX 多柔比星? 盐酸盐;Adriamycin hydrochloride;DOX;Hydroxydaunorubicin hydrochloride |
盐酸阿霉素
Doxorubicin hydrochloride （订货以英文为准）
编号：D107159
CAS号：25316-40-9
分子式：C27H30CLNO11
分子量：579.98
| 产品名称 | Doxorubicin hydrochloride |
| 中文名称 | 盐酸阿霉素 |
| CAS号 | 25316-40-9 |
| 分子式（M.F.） | C27H30CLNO11 |
| 分子量（M.W.） | 579.98 |
| 储存条件 | -20°C储存 |
| 标识符号 | https://www.aladdin-e.com/images/ghs/ghs06.jpg,https://www.aladdin-e.com/images/ghs/ghs08.jpg |
| 信号词 | Danger |
| 危害声明 | H300,H310,H330,H361 |
| 警示性声明 | P260,P264,P280,P284,P302+P350,P310 |
| 个人防护设备 | Eyeshields,Faceshields,full-face particle respirator type N100 (US),Gloves,respirator cartridge type N100 (US),type P1 (EN143) respirator filter,type P3 (EN 143) respirator cartridges |
| RTECS | HA5306000 |
| WGK德国 | 3 |
| 风险声明 (欧洲) | 26/27/28,63 |
| 安全声明（欧洲） | 28,36/37,45 |
| 危害码（欧洲） | T+ |
| UN代码 | 3462 |
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