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赭曲霉毒素A

Ochratoxin A （订货以英文为准）

编号：O102402
CAS号：303-47-9
分子式：C20H18CLNO6
分子量：403.81
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O102402-5mg 阿拉丁 5mg ¥4620.90
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O102402-1mg 阿拉丁 1mg ¥1386.90
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产品名称 Ochratoxin A
中文名称 赭曲霉毒素A
CAS号 303-47-9
MDL编码 MFCD00078079
分子式（M.F.） C20H18CLNO6
分子量（M.W.） 403.81
敏感性对湿度敏感
溶解性Soluble in chloroform (9.80 - 10.20 mg/ml), methanol (10 mg/ml), ethanol (50 mM), and DMSO (100 mM). Insoluble in water., Soluble in chloroform (9.80 - 10.20 mg/ml), methanol (10 mg/ml), ethanol (50 mM), and DMSO (100 mM). Insoluble in water.
存贮条件储存温度-20℃
密度1.4250
应用A nephrotoxic mycotoxin inhibitor of phenylalanyl-tRNA synthetases.
产品介绍Ochratoxin A is a mycotoxin isolated from the Aspergillus ochraceus mold, a common fungal presence on moldy food. Ochratoxin A demonstrates nephrotoxicity and teratogenesis in animals, and shows inhibition of bacterial, yeast, and liver FARSL (phenylalanyl-tRNA synthetases) competitive with phenylalanine. As these activities are partially attenuated by phenylalanine, Ochratoxin A is suggested to produce its effects through interacting with proteins that recognize phenylalanine as a substrate, and has been demonstrated to inhibit PAH (phenylalanine hydroxylase). Derivatives of Ochratoxin A with other amino acid moieties substituted for the phenylalanine-mimic portion of the molecule demonstrate inhibition of the aminoacyl tRNA synthetases respective to those amino acids. Ochratoxin A is described to enhance lipid peroxidation and also present DNA single strand breaks, both suggesting oxidative damage as a partial mediator of Ochratoxin A cellular effects, and EPR spectroscopy with a spin trap agent identified the production of hydroxyl radicals by Ochratoxin A in the presence of NADPH. The nephrotoxic effects of Ochratoxin A are shown to be prevented by SOD (superoxide dismutase) and catalase, further indicating oxidative damage as the mediator of Ochratoxin A toxicity. Ochratoxin A is also demonstrated to increase ATP-dependent Ca2+ pump activity in renal cortex endoplasmic reticulum.
生化机理Ochratoxin A is a mycotoxin found in food that is nephrotoxic and carcinogenic in the kidney and induces differentiation in cloned renal cell lines. Increases endoplasmic reticulum ATP-dependent Ca2+ pump activity.
别名N-[(3R)-(5-氯-8-羟基-3-甲基-1-氧代-7-苯并二氢异吡喃基)羰基]-L-苯丙氨酸;N-[(3R)-(5-Chloro-8-hydroxy-3-methyl-1-oxo-7-isochromanyl)carbonyl]-L-phenylalanine
标识符号https://www.aladdin-e.com/images/ghs/ghs09.jpg
信号词Warning
危害声明H400
警示性声明P273
个人防护设备Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
WGK德国2
风险声明 (欧洲)R50
安全声明（欧洲）S61
危害码（欧洲）N
搜索质检报告(COA)
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