| 溶解性 | DMSO 78 mg/mL Water <1 mg/mL Ethanol 2 mg/mL |
| 存贮条件 | 储存温度-20°C |
| 备注 | SB742457 is a highly selective 5-HT6 receptor antagonist with pKi of 9.63, exhibits >100-fold selectivity over other receptors. Phase 2. |
| 生化机理 | SB-742457, a 5-HT6 receptor antagonist, which extends into Alzheimer disease (AD) sufferers further highlights the therapeutic promise of this mechanistic approach. Alzheimer's disease is a devastating neurological condition characterized by a progressive decline in cognitive performance accompanied by behavioral and psychological syndromes, such as depression and psychosis. With the subsequent development of selective 5-HT6 receptor antagonists, preclinical studies in rodents and primates have elucidated the function of this receptor subtype in more detail. It is increasingly clear that blockade of 5-HT6 receptors leads to an improvement of cognitive performance in a wide variety of learning and memory paradigms and also results in anxiolytic and antidepressant-like activity. SB-742457 is generally safe and well tolerated and may be efficacious in Alzheimer disease. |
| 别名 | GSK-742457;Quinoline, 3-(phenylsulfonyl)-8-(1-piperazinyl)-;GSK-742457;Quinoline, 3-(phenylsulfonyl)-8-(1-piperazinyl)- |
SB742457,且5-HT6拮抗剂
SB742457 （订货以英文为准）
编号：S127746
CAS号：607742-69-8
分子式：C19H19N3O2S
分子量：353.44
| 产品名称 | SB742457 |
| 中文名称 | SB742457,且5-HT6拮抗剂 |
| CAS号 | 607742-69-8 |
| 分子式（M.F.） | C19H19N3O2S |
| 分子量（M.W.） | 353.44 |
| 储存条件 | -20°C储存 |
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