| 溶解性 | Soluble in DMSO (20 mg/ml), ethanol (20 mg/ml), and acetone |
| 存贮条件 | 储存温度-20°C |
| 应用 | An inducer of stored Ca2+ release. |
| 产品介绍 | Thapsigargin is a cell-permeable sesquiterpene lactone found in the roots of Thapsia garganica. It is a tumor promoter and induces the release of intracellular stored Ca2+ without hydrolysis of inositolphospholipids via inhibition of the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA; IC50=30 nM). It may be used to distinguish between discrete intracellular Ca2+ pools. Thapsigargin-induced tumor promotion and down regulation of the EGF receptor is independent of protein kinase C activation. |
| 生化机理 | Potent, cell-permeable, IP3-independent intracellular calcium releaser. Blocks the transient increase in intracellular Ca2+ induced by angiostatin and endostatin. Induces apoptosis by disrupting intracellular free Ca2+ levels; incorporated into chemotherapeutic prodrug formulations |
| 别名 | Thapsigargin;Octanoic acid;Octanoic acid |
毒胡萝卜素
Thapsigargin （订货以英文为准）
编号：T135258
CAS号：67526-95-8
分子式：C34H50O12
分子量：650.75
| 产品名称 | Thapsigargin |
| 中文名称 | 毒胡萝卜素 |
| CAS号 | 67526-95-8 |
| 分子式（M.F.） | C34H50O12 |
| 分子量（M.W.） | 650.75 |
| 储存条件 | 避光;-20°C储存;充氩 |
| Reaxys-RN | 113837 |
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