存贮条件 | 储存温度-20°C |
产品介绍 | Lorcaserin HCl是一种选择性的人源5-HT2C受体完全激动剂,Ki值为15 nM |
生化机理 | BELVIQ (lorcaserin hydrochloride) is a serotonin 2C receptor?agonist?for oral administration used for chronic weight management. Lorcaserin is a highly selective 5-HT2C receptor agonist developed for the treatment of obesity. In rats, lorcaserin led to dose-dependent wt. loss. Lorcaserin proved safe and well tolerated in healthy volunteers and obese patients. In a phase II clin. study, patients administered 20 mg/day lorcaserin achieved an av. wt. loss of 3.6 kg (7.9 lbs), which was significantly greater than the av. wt. loss of 0.3 kg (0.7 lbs) in the placebo group. A phase III clin. trial is ongoing to evaluate the long-term safety and efficacy of lorcaserin in patients with obesity. |
别名 | 绿卡色林盐酸盐; (R)-8-氯-1-甲基-2,3,4,5-四氢-1H-3-苯并氮杂卓盐酸盐;(R)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride |
氯卡色林盐酸盐
Lorcaserin HCl (订货以英文为准)
编号:L129791
CAS号:846589-98-8
分子式:C11H14CLN.HCL
分子量:232.15
产品名称 | Lorcaserin HCl |
中文名称 | 氯卡色林盐酸盐 |
CAS号 | 846589-98-8 |
分子式(M.F.) | C11H14CLN.HCL |
分子量(M.W.) | 232.15 |
WGK德国 | 3 |
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