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盐酸马尼地平

Manidipine 2HCl （订货以英文为准）

编号：M129521
CAS号：89226-75-5
分子式：C35H40CL2N4O6
分子量：683.62
货号 品牌 包装 目录价 您的价格 库存 数量 购买
M129521-50mg 阿拉丁 50mg ¥59.90
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M129521-25mg 阿拉丁 25mg ¥29.90
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M129521-100mg 阿拉丁 100mg ¥61.90
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M129521-1g 阿拉丁 1g ¥213.90
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M129521-500mg 阿拉丁 500mg ¥160.90
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M129521-5g 阿拉丁 5g ¥805.90
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产品名称 Manidipine 2HCl
中文名称 盐酸马尼地平
CAS号 89226-75-5
MDL编码 MFCD00896434
分子式（M.F.） C35H40CL2N4O6
分子量（M.W.） 683.62
储存条件 -20°C储存
溶解性DMSO 21 mg/mL Water <1 mg/mL Ethanol <1 mg/mL
存贮条件储存温度-20°C
备注Manidipine 2HCl is a HCl salt form of Manidipine, which is a calcium channel blocker with IC50 of 2.6 nM, used clinically as an antihypertensive. Phase 4.
生化机理Manidipine dihydrochloride is a dihydropyridine compound and a calcium channel blocker for Ca2+ current with IC50 of 2.6 nM. Manidipine is described to block T-type Ca2+ channels specifically and is also described to have a high selectivity for the vasculature, presenting negligible cardiodepression as compared to other Ca2+ channel antagonists. Manidipine is also described to not significantly affect norepinephrine levels, suggesting a lack of sympathetic activation with this compound. Manidipine reduces pro-inflammatory cytokines secretion in human endothelial cells and macrophages. Manidipine, unlike other third-generation dihydropyridine derived drugs, blocks T-type calcium channels present in the efferent glomerular arterioles, reducing intraglomerular pressure and microalbuminuria.
别名1,4-二氢-2,6-二甲基-4-(3-硝基苯基)-3,5-吡啶二羧酸-2-[4-(二苯基甲基)-1-哌嗪基]乙基甲基酯二盐酸盐;2-[4-(二苯基甲基)-1-哌嗪基]乙基甲基-1,4-二氢-2,6-二甲基-4-(3-硝基苯基)-3,5-吡啶二羧酸酯二盐酸盐;1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 2-[4-(Diphenylmethyl)-1-piperazinyl]ethyl Methyl Ester Dihydrochloride;2-[4-(Diphenylmethyl)-1-piperazinyl]ethyl Methyl 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate Dihydrochloride
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