| 溶解性 | Soluble in DMSO (10 mg/ml at 40°C), ethanol (6 mg/ml at 40°C), and DMF (>25 mg/ml), dichloromethane, ethyl acetate, and methanol. Insoluble in water. |
| 存贮条件 | 储存温度-20°C |
| 应用 | TRAM-34 is a selective and potent inhibitor of the intermediate-conductance Ca2+-activated K+ channel (IKCa1, KCa3.1) with Kd of 20 nM, 200- to 1500-fold selective over other ion channels, and does not block cytochrome P450. |
| 产品介绍 | TRAM-34 has been shown to be an inhibitor of cloned and native IK1 channels in human T lymphocytes. These K+ channels have been implicated in over-proliferation of cells. Inhibition of IK1 channels has been demonstrated to modulate cell proliferation depending on the concentration of TRAM-34. Mechanistic studies have shown that TRAM-34 may cause a halt in cell growth at the G0/G1 phase. |
| 备注 | TRAM-34 is a selective and potent inhibitor of the intermediate-conductance Ca2+-activated K+ channel (IKCa1, KCa3.1) with Kd of 20 nM, 200- to 1500-fold selective over other ion channels, and does not block cytochrome P450. |
| 别名 | 1-[(2-氯苯基)二苯甲基]-1H-吡唑;1-[(2-Chlorophenyl)diphenylmethyl]-1H-pyrazole |
TRAM-34,K Ca 3.1通道阻滞剂
TRAM-34 （订货以英文为准）
编号：T129575
CAS号：289905-88-0
分子式：C22H17CLN2
分子量：344.84
| 产品名称 | TRAM-34 |
| 中文名称 | TRAM-34,K Ca 3.1通道阻滞剂 |
| CAS号 | 289905-88-0 |
| 分子式（M.F.） | C22H17CLN2 |
| 分子量（M.W.） | 344.84 |
| 储存条件 | -20°C储存 |
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