| 溶解性 | DMSO |
| 存贮条件 | 储存温度2-8℃ |
| 生化机理 | Haspin is a serine/threonine kinase that phosphorylates Thr-3 of histone H3 in mitosis that has emerged as a possible cancer therapeutic target. CHR-6494 is a first-in-class Haspin inhibitor with a wide spectrum of anticancer effects. Recent research showed that CHR-6494 reduces H3T3ph levels in a dose-dependent manner and causes a mitotic catastrophe characterized by metaphase misalignment, spindle abnormalities and centrosome amplification. From the cellular standpoint, the identified small-molecule Haspin inhibitor causes arrest in G2/M and subsequently apoptosis. Importantly, ex vivo assays also demonstrate its anti-angiogenetic features; in vivo, it shows antitumor potential in xenografted nude mice without any observed toxicity. |
| 别名 | ; |
CHR-6494,haspin 抑制剂
CHR-6494 （订货以英文为准）
编号：C124894
CAS号：1333377-65-3
| 产品名称 | CHR-6494 |
| 中文名称 | CHR-6494,haspin 抑制剂 |
| CAS号 | 1333377-65-3 |
| 储存条件 | -20°C储存 |
搜索质检报告(COA)
搜索MSDS
相关产品
¥ 240.00
C416-01
¥ 240.00
C415-01
¥ 4250.00
2118S-100ul
¥ 989.00
R0581S-200units
小艺 
