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VX-809 (Lumacaftor)

VX-809 (Lumacaftor) （订货以英文为准）

编号：V127916
CAS号：936727-05-8
分子式：C24H18F2N2O5
分子量：452.41
货号 品牌 包装 目录价 您的价格 库存 数量 购买
V127916-5mg 阿拉丁 5mg ¥514.90
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V127916-50mg 阿拉丁 50mg ¥1852.90
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V127916-10mg 阿拉丁 10mg ¥802.90
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产品名称 VX-809 (Lumacaftor)
中文名称 VX-809 (Lumacaftor)
CAS号 936727-05-8
分子式（M.F.） C24H18F2N2O5
分子量（M.W.） 452.41
储存条件 -20°C储存
溶解性DMSO 91 mg/mL Water <1 mg/mL Ethanol 6 mg/mL
存贮条件储存温度-20°C
产品介绍VX-809 (Lumacaftor)通过促进突变型CFTR(F508del-CFTR)的成熟，从而纠正常见于囊性纤维化的CFTR突变，EC50为0.1 μM。
备注VX-809 acts to correct CFTR mutations common in cystic fibrosis by increasing mutant CFTR (F508del-CFTR) maturation,EC50 of 0.1 μM. Phase 3.
生化机理VX-809 is the second investigational oral candidate compound for the treatment of cystic fibrosis (CF). VX-809 may act to restore the function of the cystic fibrosis transmembrane conductance regulator (CFTR) protein, the defective cell membrane protein responsible for the progression of CF. VX-809 defects in the CFTR protein affect the transport of chloride and other ions across cells, and lead to the accumulation of thick, sticky mucus in the lungs of patients with CF. This mucus fosters chronic infection and inflammation, and results in irreversible lung damage.
别名VX 809; 3-[6-[[[1-(2,2-二氟-1,3-苯并二氧戊环-5-基)环丙基]羰基]氨基]-3-甲基-2-吡啶基]苯甲酸;VX 809; VX809; Lumacaftor; VRT 826809;3-[6-[[[1-(2,2-Difluoro-1,3-benzodioxol-5-yl)cyclopropyl]carbonyl]amino]-3-methyl-2-pyridinyl]benzoic acid
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