| 溶解性 | DMSO 97 mg/mL Water <1 mg/mL Ethanol <1 mg/mL |
| 存贮条件 | 储存温度-20°C |
| 备注 | IKK 16 is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively. |
| 生化机理 | Description： IC50 value: 40nM( forIKK-2);70nM(for Ikk complex);200nM(for Ikk-1) IKK 16 is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively. IKKs play an important role in the NF-KB signal pathway. In vitro: K IKK-16 inhibits TNFα-stimulated expression of the adhesion molecules E-selectin, ICAM-1, and VCAM-1 in HUVEC cells. Although IKK-16 shows activity in the IFNγ-induced expression of β2 microglobulin or HLA-DR, its potency in these assays is 4- to 10-fold weaker. 1]. In vivo: N/A Clinical trial: N/A |
| 别名 | Methanone, [4-[(4-benzo[b]thien-2-yl-2-pyrimidinyl)amino]phenyl][4-(1-pyrrolidinyl)-1-piperidinyl]-;Methanone, [4-[(4-benzo[b]thien-2-yl-2-pyrimidinyl)amino]phenyl][4-(1-pyrrolidinyl)-1-piperidinyl]- |
IKK-16(IKK抑制剂VII)
IKK-16 (IKK Inhibitor VII) （订货以英文为准）
编号：I129698
CAS号：873225-46-8
分子式：C28H29N5OS
分子量：483.63
| 产品名称 | IKK-16 (IKK Inhibitor VII) |
| 中文名称 | IKK-16(IKK抑制剂VII) |
| CAS号 | 873225-46-8 |
| 分子式（M.F.） | C28H29N5OS |
| 分子量（M.W.） | 483.63 |
| 储存条件 | -20°C储存 |
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