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乙氧基试卤灵

Resorufin ethyl ether （订货以英文为准）

编号：R131523
CAS号：5725-91-7
分子式：C14H11NO3
分子量：241.24
货号 品牌 包装 目录价 您的价格 库存 数量 购买
R131523-25mg 阿拉丁 25mg ¥2366.90
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R131523-5mg 阿拉丁 5mg ¥660.90
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R131523-1mg 阿拉丁 1mg ¥165.90
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产品名称 Resorufin ethyl ether
中文名称 乙氧基试卤灵
CAS号 5725-91-7
分子式（M.F.） C14H11NO3
分子量（M.W.） 241.24
储存条件 -20°C储存
溶解性Soluble in DMSO (5 mg/mL), ethanol (5 mg/mL), chloroform, dichloromethane, DMF (5 mg/mL), alcohols, and methanol. Insoluble in water.
存贮条件储存温度-20°C
应用7-Ethoxyresorufin (7-ER) is a substrate used in environmental toxicology studies to monitor ethoxyresorufin-O-deethylase catalytic activity in the EROD assay. The EROD assay monitors the induction of the xenobiotic-metabolizing enzyme cytochrome P-450 (CYP) 1A1 and is a widely used biomarker for exposure of wildlife to substances that bind the aryl hydrocarbon (Ah) receptor. It provides evidence of receptor-mediated induction of cytochrome P450-dependant monooxygenases (the CYP1A subfamily specifically) by xenobiotic chemicals.
产品介绍7-Ethoxyresorufin is a fluorimetric substrate and suicide inhibitor of CYP (cytochrome P450). Also shown to inhibit several reductase enzymes, specifically CYPOR (NADPH-P450 reductase). The binding to CYP (cytochrome P450) is thought to inhibit the vasorelaxant response to acetylcholine. 7-Ethoxyresorufin has also demonstrated inhibition of NO synthesis by uncoupling neuronal NOS1 (nitric oxide synthase); it is a noncompetitive inhibitor of neuronal NOS1 with respect to L-arginine with a Ki value of 0.76 +/- 0.06 μM. 7-Ethoxyresorufin is a substate of CYP1A1.
别名7-乙氧基-3H-吩恶嗪-3-酮;7-乙氧基resorufin;7-ER;Ethoxyresorufin;7-Ethoxy-3H-phenoxazin-3-one;O7-Ethylresorufin;7-Ethoxyresorufin;7-ER;7-Ethoxy Resorufin
WGK德国3
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