CHIR-124,新型和Chk1抑制剂

CHIR-124 (订货以英文为准)

编号:C125171
CAS号:405168-58-3
货号 品牌 包装 目录价 您的价格 库存 数量 购买
C125171-25mg 阿拉丁 25mg ¥1999.90
C125171-100mg 阿拉丁 100mg ¥5199.90
C125171-5mg 阿拉丁 5mg ¥579.90
C125171-1mg 阿拉丁 1mg ¥192.90
C125171-50mg 阿拉丁 50mg ¥3199.90
产品名称 CHIR-124
中文名称 CHIR-124,新型和Chk1抑制剂
CAS号 405168-58-3
储存条件 -20°C储存
溶解性DMSO 7 mg/mL Water <1 mg/mL Ethanol <1 mg/mL
存贮条件储存温度-20°C
备注CHIR-124 is a novel and potent Chk1 inhibitor with IC50 of 0.3 nM. It shows 2,000-fold selectivity against Chk2, 500- to 5,000-fold less activity against CDK2/4 and Cdc2.
生化机理CHIR-124 is a novel and potent chk1 inhibitor with an IC50 of 0.3 nM. Chk1 kinase is a critical regulator of both the S and G2/M phase cell cycle checkpoints in response to DNA damage. CHIR-124 has been shown that inhibitors of chk1 can selectively sensitize tumor cells with mutant p53 to genotoxic agents.
别名(S)-3-(1H-benzo[d]imidazol-2-yl)-6-chloro-4-(quinuclidin-3-ylamino)quinolin-2(1H)-one;(S)-3-(1H-benzo[d]imidazol-2-yl)-6-chloro-4-(quinuclidin-3-ylamino)quinolin-2(1H)-one
搜索质检报告(COA)
搜索MSDS
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