| 溶解性 | Soluble in alka line solutions (pH 10 or more), and most polar organic solvents.. Insoluble in water. |
| 存贮条件 | 储存温度2-8℃ |
| 应用 | Cinoxacin is a synthetic antimicrobial commonly used in urinary tract infections that are caused by Escherichia coli, Proteus mirabilis, Proteus vulgaris, Klebsiella species, and Enterobacter species.. It is a quinolone gyrase inhibitor. It is used to study the rat renal organic anion transporter 1 (OAT1). It is used to study fluoroquinolone-resistant Streptococcus pyogenes. |
| 产品介绍 | Cinoxacin is an antibacterial quinolone analog of oxolinic acid. The compound has been documented to block DNA synthesis through inhibition of Topo II (DNA gyrase) as well as topoisomerase IV. Cinoxacin has been observed to block both topoisomerse IV in both prokaryotic and eukaryotic cell lines. Due to the inhibiting activity of Cinoxacin the compound has displayed toxicity against eukaryotic cells. In vitro studies have shown the renal damage caused by Cinoxacin to be attributed to deposition of Cinoxacin crystals in the urinary tract. |
| 生化机理 | Cinoxacin interferes with DNA replication by inhibiting DNA gyrase and topoisomerase IV (topo IV) through tight DNA binding. Cinoxacin allows for proper replicated DNA separation. Therefore, the inhibition of Cinoxacin inhibits DNA replication and cell division. |
| 别名 | 西诺沙星;1-Ethyl-1,4-dihydro-4-oxo-[1,3]dioxolo[4,5-g]cinnoline-3-carboxylic acid |
西诺沙星
Cinoxacin （订货以英文为准）
编号：C135059
CAS号：28657-80-9
分子式：C12H10N2O5
分子量：262.22
| 产品名称 | Cinoxacin |
| 中文名称 | 西诺沙星 |
| CAS号 | 28657-80-9 |
| MDL编码 | MFCD00056776 |
| 分子式（M.F.） | C12H10N2O5 |
| 分子量（M.W.） | 262.22 |
| 储存条件 | -20°C储存 |
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