| 溶解性 | DMSO |
| 存贮条件 | 储存温度-20°C |
| 生化机理 | Voreloxin is a small molecule and a naphthyridine analogue with antineoplastic activity. Vosaroxin intercalates into DNA in a site-specific manner and blocks the re-ligation process carried out by topoisomerase II during DNA replication. As a result, inhibition of DNA replication, RNA and protein synthesis occurs, followed by cell cycle arrest at G2 phase and induced p53-independent apoptosis. This agent shows a favorable toxicity profile in several aspects: it does not generate reactive oxygen species, as do anthracyclines, reducing the risk of cardiotoxicity; it is not a P-glycoprotein (P-gp) substrate, and thereby evades the common mechanism for multidrug resistance; and it has limited distribution to normal tissues and a more chemically stable molecular structure. |
Voreloxin,拓扑异构酶 II抑制剂
Voreloxin （订货以英文为准）
编号：V125786
CAS号：175414-77-4
分子式：C18H19N5O4S
分子量：401.44
| 产品名称 | Voreloxin |
| 中文名称 | Voreloxin,拓扑异构酶 II抑制剂 |
| CAS号 | 175414-77-4 |
| 分子式（M.F.） | C18H19N5O4S |
| 分子量（M.W.） | 401.44 |
| 储存条件 | -20°C储存 |
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