| 溶解性 | DMSO |
| 存贮条件 | 储存温度-20°C |
| 生化机理 | NKP608 is a non-peptidic derivative of 4-aminopiperidine which acts as a selective, specific and potent antagonist at the neurokinin-1 (NK-1) receptor both in vitro and in vivo. In vitro, the binding of NKP608 to bovine retina was characterized by an IC50 of 2.6+/-0.4 nM, whereas the compound's affinity to other receptor binding sites, including NK-2 and NK-3, was much lower. Species differences in IC(50) values with NKP608 were less pronounced than with previously described NK-1 receptor antagonists, being 13+/-2 and 27+/-2 nM in gerbil midbrain and rat striatum, respectively. In vivo, using the hind foot thumping model in gerbils, NKP608 exhibited a potent NK-1 antagonistic activity following oral administration (ID(50)=0.23 mg/kg; 2 h pretreatment), supporting a central activity of NKP608. NKP608 may prove a useful anxiolytic compound. |
| 别名 | ; |
NKP608
NKP608 （订货以英文为准）
编号：N125026
CAS号：177707-12-9
| 产品名称 | NKP608 |
| 中文名称 | NKP608 |
| CAS号 | 177707-12-9 |
| 储存条件 | -20°C储存 |
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