| 溶解性 | 25°C: DMSO |
| 存贮条件 | 储存温度-20°C |
| 生化机理 | Description: IC50 Value: 5uM (inhibit U251, SF188, T98G cell growth in monolayer after 72h) VAL-083 surpasses temozolomide (TMZ) activity and inhibits cancer stem cells (CSCs) providing a new potential treatment option for glioblastoma multiforme (GBM). VAL-083 inhibited U251 and SF188 cell growth in monolayer better than TMZ and caused apoptosis [1]. in vitro: VAL-083 inhibited U251 and SF188 cell growth in monolayer and as neurospheres better than TMZ and caused apoptosis after 72 hr. In the colony formation assay, VAL-083 (5 uM) suppressed SF188 growth by about 95%. T98G cells are classically TMZ-resistant and express MGMT, but VAL-083 inhibited their growth in monolayer after 72 hr in a dose-dependent manner (IC50, 5 uM). VAL-083 also inhibited the growth of CSCs (BT74, GBM4, and GBM8) by 80-100% in neurosphere self-renewal assays. Conversely, there was minimal effect on normal human neural stem cells [1]. in vivo: N/A Clinical trial: Safety Study of VAL-083 in Pat |
| 别名 | ;Dianhydrodulcitol;Dianhydrogalactitol;VAL083 |
Val-083,烷化剂
VAL-083 （订货以英文为准）
编号：V125883
CAS号：23261-20-3
分子式：C6H10O4
分子量：146.14
| 产品名称 | VAL-083 |
| 中文名称 | Val-083,烷化剂 |
| CAS号 | 23261-20-3 |
| 分子式（M.F.） | C6H10O4 |
| 分子量（M.W.） | 146.14 |
| 储存条件 | -20°C储存 |
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