1. 首页
  2. 产品目录

U0126-EtOH,抑制剂

U0126-EtOH （订货以英文为准）

编号：U127670
CAS号：1173097-76-1
分子式：C18H16N6S2.C2H6O
分子量：426.56
货号 品牌 包装 目录价 您的价格 库存 数量 购买
U127670-25mg 阿拉丁 25mg ¥226.90
请登录
U127670-500mg 阿拉丁 500mg ¥4325.90
请登录
U127670-100mg 阿拉丁 100mg ¥814.90
请登录
产品名称 U0126-EtOH
中文名称 U0126-EtOH,抑制剂
CAS号 1173097-76-1
分子式（M.F.） C18H16N6S2.C2H6O
分子量（M.W.） 426.56
储存条件 -20°C储存
溶解性DMSO ≥83mg/mL Water <1.2mg/mL Ethanol <1.2mg/mL
存贮条件储存温度-20°C
产品介绍U0126-EtOH(U-0126)是MEK1和2选择性抑制剂，IC50分别为70nM和60nM，对ΔN3-S218E/S222D MEK的亲和力比PD098059强100倍。
备注U0126-EtOH is a highly selective inhibitor of MEK1/2 with IC50 of 0.07 μM/0.06 μM, 100-fold higher affinity for ΔN3-S218E/S222D MEK than PD098059.
生化机理U0126-EtOH functionally antagonizes AP- 1 transcriptional activity and blocks the production of a variety of cytokines and metalloproteinases involved in the inflammatory response. U0126-EtOH inhibits T cell proliferation in response to antigenic stimulation or cross-linked anti-CD3 plus anti-CD28 Abs without effect on IL-2-induced proliferation by down-regulating IL-2 mRNA levels . A recent study shows that U0126-EtOH antagonizes resveratrol-induced apoptosis in castration-resistant human prostate cancer C4-2 cells, inhibits mitochondrial function and shifts cells to aerobic glycolysis independently of MEK .
别名U 0126;U-0126 ;2,3-双[氨基[(2-氨基苯基)硫]亚甲基]丁二腈乙醇盐;U 0126;U-0126;2,3-Bis[amino[(2-aminophenyl)thio]methylene]butanedinitrile ethanol salt
安全声明（欧洲）S24/25;
搜索质检报告(COA)
搜索MSDS
相关产品