| 别名 | ; |
2,3-二溴-2,3-二甲基丁烷
2,3-Dibromo-2,3-dimethylbutane （订货以英文为准）
编号：D155004
CAS号：594-81-0
分子式：C6H12BR2
分子量：243.97
| 产品名称 | 2,3-Dibromo-2,3-dimethylbutane |
| 中文名称 | 2,3-二溴-2,3-二甲基丁烷 |
| CAS号 | 594-81-0 |
| MDL编码 | D155004 |
| 分子式（M.F.） | C6H12BR2 |
| 分子量（M.W.） | 243.97 |
| 储存条件 | 2-8°C储存 |
| Reaxys-RN | 1862172 |
技术规格
| Background: | NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B heterodimeric p65-p50 and p65-c-Rel complexes are transcriptional activators. The inhibitory effect of I-kappa-B upon NF-kappa-B the cytoplasm is exerted primarily through the interaction with p65. p65 shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. |
| Applications: | WB, IHC, IF |
| Name of antibody: | RELA (Phospho-Thr254) |
| Immunogen: | Synthetic peptide of human RELA (Phospho-Thr254) |
| Full name: | v-rel reticuloendotheliosis viral oncogene homolog A (avian) (Phospho-Thr254) |
| Synonyms： | p65; NFKB3 |
| SwissProt: | Q04206 |
| IHC positive control: | Human breast carcinoma |
| IHC Recommend dilution: | 50-100 |
| WB Predicted band size: | 65 kDa |
| WB Positive control: | NIH/3T3 cells treated with TNF-α |
| WB Recommended dilution: | 500-1000 |
| IF Positive control: | Hela cells |
| IF Recommended dilution | 100-200 |
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