| 溶解性 | DMSO 24 mg/mL Water <1 mg/mL Ethanol 14 mg/mL |
| 存贮条件 | 储存温度-20°C |
| 应用 | AGI-5198(IDH C35)是剂量依赖的R132H-IDH1抑制剂 |
| 产品介绍 | AGI-5198 is the first highly potent and selective inhibitor of IDH1 R132H/R132C mutants with IC50 of 0.07 μM/0.16 μM. |
| 备注 | AGI-5198 is the first highly potent and selective inhibitor of IDH1 R132H/R132C mutants with IC50 of 0.07 μM/0.16 μM. |
| 生化机理 | Description:IC50 Value: N/AAGI-5198, a novel R132H-IDH1 inhibitor, identified through a high-throughput screen blocked, in a dose-dependent manner, the ability of the mutant enzyme (mIDH1) to produce R-2-hydroxyglutarate (R-2HG). The recent discovery of mutations in metabolic enzymes has rekindled interest in harnessing the altered metabolism of cancer cells for cancer therapy. Isocitrate dehydrogenase 1 (IDH1) is one potential drug target, which is mutated in multiple human cancers [1].in vitro: N/Ain vivo: N/AClinical trial: N/A |
| 别名 | ;IDH-C35;AGI5198;AGI 5198;IDH C35;N-Cycohexyl-2-(N-(3-fluorophenyl)-2-(2-methyl-1H-imidazol-1-yl)acetamido)-2-(o-tolyl)acetamide; N-[2-(Cyclohexylamino)-1-(2-methylphenyl)-2-oxoethyl]-N-(3-fluorophenyl)-2-methyl-1H-imidazole-1-acetamide |
AGI-5198,突变体异柠檬酸脱氢酶1（mIDH1）的有效抑制剂
AGI-5198 （订货以英文为准）
编号：A126546
CAS号：1355326-35-0
分子式：C27H31FN4O2
分子量：462.56
| 产品名称 | AGI-5198 |
| 中文名称 | AGI-5198,突变体异柠檬酸脱氢酶1（mIDH1）的有效抑制剂 |
| CAS号 | 1355326-35-0 |
| 分子式（M.F.） | C27H31FN4O2 |
| 分子量（M.W.） | 462.56 |
| 储存条件 | -20°C储存 |
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