| 溶解性 | 25°C: DMSO |
| 存贮条件 | 储存温度-20°C |
| 生化机理 | Description:IC50 Value: 1.2 nM (whole-cell assay);6.2 nM (cell-free assay) [1]PF-03084014 is a novel gamma-secretase inhibitor that reduces amyloid-beta (Abeta) production with an in vitro IC(50) of 1.2 nM (whole-cell assay) to 6.2 nM (cell-free assay).in vitro: PF-03084014 inhibits Notch-related T- and B-cell maturation in an in vitro thymocyte assay with an EC(50) of 2.1 microM. A single acute dose showed dose-dependent reduction in brain, cerebrospinal fluid (CSF), and plasma Abeta in Tg2576 mice as measured by enzyme-linked immunosorbent assay and immunoprecipitation (IP)/mass spectrometry (MS) [1]. The ability of PF-03084014 to inhibit gamma-secretase activity was shown by the reduction of endogenous NICD levels and by the downregulation of Notch target genes Hes-1 and cMyc in the T-cell acute lymphoblastic leukemia (T-ALL) cell line HPB-ALL. PF-03084014 caused cell growth inhibition of several T-ALL cell lines via cell cycle arrest and induction |
| 别名 | ; |
PF-3084014
PF-3084014 （订货以英文为准）
编号：P127448
CAS号：1290543-63-3
分子式：C27H41F2N5O
分子量：489.64
| 产品名称 | PF-3084014 |
| 中文名称 | PF-3084014 |
| CAS号 | 1290543-63-3 |
| MDL编码 | MFCD19980705 |
| 分子式（M.F.） | C27H41F2N5O |
| 分子量（M.W.） | 489.64 |
| 储存条件 | -20°C储存 |
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