| 溶解性 | DMSO |
| 存贮条件 | 储存温度2-8℃ |
| 生化机理 | S0859, an N-cyanosulphonamide compound, reversibly inhibited NBC-mediated pH(i) recovery (K (i)=1.7 microM, full inhibition at approximately 30 microM). Na(+)-coupled HCO(3)(-) transporters (NBCs) mediate the transport of bicarbonate ions across cell membranes and are thus ubiquitous regulators of intracellular pH. NBC dysregulation is associated with a range of diseases; for instance, NBCn1 is strongly up-regulated in a model of ErbB2-dependent breast cancer, a malignant and widespread cancer with no targeted treatment options, and single-nucleotide polymorphisms in NBCn1 genetically link to breast cancer development and hypertension. Treatment with NBC inhibitor S0859 significantly increased caspase-3 activity and elevated the number of apoptotic EC. S0859 is potentially important for probing the transporter's functional role in heart and other tissues. |
| 别名 | ; |
S0859,Na+/HCO3- 共转运体 (NBC) 抑制剂
S0859 （订货以英文为准）
编号：S127983
CAS号：1019331-10-2
分子式：C29H24CLN3O3S
分子量：530.04
| 产品名称 | S0859 |
| 中文名称 | S0859,Na+/HCO3- 共转运体 (NBC) 抑制剂 |
| CAS号 | 1019331-10-2 |
| 分子式（M.F.） | C29H24CLN3O3S |
| 分子量（M.W.） | 530.04 |
| 储存条件 | -20°C储存 |
| 标识符号 | https://www.aladdin-e.com/images/ghs/ghs07.jpg,https://www.aladdin-e.com/images/ghs/ghs08.jpg |
| 信号词 | Danger |
| 危害声明 | H302-H350-H360 |
| 警示性声明 | P201-P308 + P313 |
| 个人防护设备 | Eyeshields, Gloves, type P2 (EN 143) respirator cartridges |
| RTECS | MU1050000 |
| WGK德国 | 3 |
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