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S0859,Na+/HCO3- 共转运体 (NBC) 抑制剂

S0859 （订货以英文为准）

编号：S127983
CAS号：1019331-10-2
分子式：C29H24CLN3O3S
分子量：530.04
货号 品牌 包装 目录价 您的价格 库存 数量 购买
S127983-10mg 阿拉丁 10mg ¥677.90
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S127983-5mg 阿拉丁 5mg ¥388.90
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S127983-50mg 阿拉丁 50mg ¥2371.90
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S127983-25mg 阿拉丁 25mg ¥1482.90
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S127983-100mg 阿拉丁 100mg ¥3794.90
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产品名称 S0859
中文名称 S0859,Na+/HCO3- 共转运体 (NBC) 抑制剂
CAS号 1019331-10-2
分子式（M.F.） C29H24CLN3O3S
分子量（M.W.） 530.04
储存条件 -20°C储存
溶解性DMSO
存贮条件储存温度2-8℃
生化机理S0859, an N-cyanosulphonamide compound, reversibly inhibited NBC-mediated pH(i) recovery (K (i)=1.7 microM, full inhibition at approximately 30 microM). Na(+)-coupled HCO(3)(-) transporters (NBCs) mediate the transport of bicarbonate ions across cell membranes and are thus ubiquitous regulators of intracellular pH. NBC dysregulation is associated with a range of diseases; for instance, NBCn1 is strongly up-regulated in a model of ErbB2-dependent breast cancer, a malignant and widespread cancer with no targeted treatment options, and single-nucleotide polymorphisms in NBCn1 genetically link to breast cancer development and hypertension. Treatment with NBC inhibitor S0859 significantly increased caspase-3 activity and elevated the number of apoptotic EC. S0859 is potentially important for probing the transporter's functional role in heart and other tissues.
别名;
标识符号https://www.aladdin-e.com/images/ghs/ghs07.jpg,https://www.aladdin-e.com/images/ghs/ghs08.jpg
信号词Danger
危害声明H302-H350-H360
警示性声明P201-P308 + P313
个人防护设备Eyeshields, Gloves, type P2 (EN 143) respirator cartridges
RTECSMU1050000
WGK德国3
搜索质检报告(COA)
搜索MSDS
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