| 溶解性 | DMSO 24 mg/mL heatWater <1 mg/mL Ethanol <1 mg/mL |
| 存贮条件 | 储存温度-20°C |
| 备注 | CYC116 is a potent inhibitor of Aurora A/B with Ki of 8.0 nM/9.2 nM, is less potent to VEGFR2 (Ki of 44 nM), with 50-fold greater potency than CDKs, not active against PKA, Akt/PKB, PKC, no effect on GSK-3α/β, CK |
| 生化机理 | CYC-116 is an orally bioavailable，small molecule Aurora kinase/VEGFR2 inhibitor with antineoplastic activity. CYC-116 inhibits Aurora kinases A and B and VEGFR2, resulting in disruption of the cell cycle, rapid cell death, and the inhibition of angiogenesis. |
| 别名 | 4-(2-amino-4-methylthiazol-5-yl)-N-(4-morpholinophenyl)pyrimidin-2-amine;4-(2-amino-4-methylthiazol-5-yl)-N-(4-morpholinophenyl)pyrimidin-2-amine |
CYC116,Aurora A/B抑制剂
CYC116 （订货以英文为准）
编号：C126929
CAS号：693228-63-6
分子式：C18H20N6OS
分子量：368.46
| 产品名称 | CYC116 |
| 中文名称 | CYC116,Aurora A/B抑制剂 |
| CAS号 | 693228-63-6 |
| 分子式（M.F.） | C18H20N6OS |
| 分子量（M.W.） | 368.46 |
| 储存条件 | -20°C储存 |
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