| 应用 | Pentoxifylline是竞争性非选择性磷酸二酯酶(PDE)抑制剂 |
| 产品介绍 | Pentoxifylline is a competitive nonselective phosphodiesterase inhibitor. Target: PDE Pentoxifylline is a competitive nonselective phosphodiesterase inhibitor which raises intracellular cAMP, activates PKA, inhibits TNF and leukotriene synthesis, and reduces inflammation and innate immunity. In addition, pentoxifylline improves red blood cell deformability, reduces blood viscosity and decreases the potential for platelet aggregation and thrombus formation. Pentoxifylline is also an antagonist at adenosine 2 receptors . Pentoxifylline is generally well tolerated. Based on the totality of the available evidence, it is possible that pentoxifylline could have a place in the treatment of IC as a means of improving walking distance and as a complimentary treatment assuming all other essential measures such as lifestyle change, exercise and treatment for secondary prevention have been taken into account . Pentoxifylline reduce AST and ALT levels and may improve liver histological scores in patients with NALFD/NASH, but did not appear to affect cytokines. Large, prospective, and well-designed randomized, controlled studies are needed to address this issue . |
| 别名 | 3,7-二氢-3,7-二甲基-1-(5-氧代己基)-1H-嘌呤-2,6-二酮; 3,7-二甲基-1-(5-氧代己基)黄嘌呤; 1-(5-氧代己基)可可碱; 己酮可可碱;3,7-Dihydro-3,7-dimethyl-1-(5-oxohexyl)-1H-purine-2,6-dione; 3,7-Dimethyl-1-(5-oxohexyl)xanthine; 1-(5-Oxohexyl)theobromine; BL-191; PTX; Oxpentifylline |
己酮可可碱
Pentoxifylline (订货以英文为准)
编号:P160702
CAS号:6493-05-6
分子式:C13H18N4O3
分子量:278.31
| 产品名称 | Pentoxifylline |
| 中文名称 | 己酮可可碱 |
| CAS号 | 6493-05-6 |
| 分子式(M.F.) | C13H18N4O3 |
| 分子量(M.W.) | 278.31 |
| 储存条件 | -20°C储存 |
| Reaxys-RN | 611622 |
| 信号词 | Warning |
| 危害声明 | H315-H319-H335 |
| 警示性声明 | P261-P305 + P351 + P338 |
| 个人防护设备 | dust mask type N95 (US), Eyeshields, Gloves |
| WGK德国 | 3 |
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