| 熔点 | 246-256℃ |
| 溶解性 | Soluble in DMSO (10 mg/ml), chloroform (10 mg/ml), dioxane, pyridine, glacial acetic acid, and DMF. Insoluble in water |
| 存贮条件 | 储存温度:-20℃ |
| 密度 | 1.6400 |
| 应用 | A protein synthesis-inhibiting antibiotic |
| 产品介绍 | Thiostrepton is a cyclic peptide antibiotic, densely packed with thiazoles and other structurally intriguing moieties. Thiostrepton exhibits antibiotic activity through blockade of ribosome turnover after an elongation step in protein synthesis by inhibiting both the dissociation of elongation factor G (EF-G) from the ribosome and the release of inorganic phosphate from EF-G following GTP hydrolysis. Thiostrepton is also described to show efficacy against cancer cell growth through downregulation of the forkhead box M1 (FOXM1) transcription factor, commonly overexpressed in many malignancies. Thiostrepton is an inhibitor of FOXM1 |
| 生化机理 | 肽抗生素，阻止延长因子G（EF-G）和GTP结合到50S核糖体亚单元上 |
| 别名 | 硫链丝菌素;Bryamycin; Thiactin; Alaninamide;FOXM1 Inhibitor I, FOXM1 Inhibitor I |
硫链丝菌肽
Thiostrepton （订货以英文为准）
编号：T102394
CAS号：1393-48-2
分子式：C72H85N19O18S5
分子量：1664.89
| 产品名称 | Thiostrepton |
| 中文名称 | 硫链丝菌肽 |
| CAS号 | 1393-48-2 |
| MDL编码 | MFCD00135828 |
| 分子式（M.F.） | C72H85N19O18S5 |
| 分子量（M.W.） | 1664.89 |
| 储存条件 | 避光;-20°C储存;干燥 |
| Reaxys-RN | 761557 |
| 个人防护设备 | Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter |
| RTECS | UQ4150000 |
| WGK德国 | 1 |
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