| 溶解性 | DMSO |
| 存贮条件 | 储存温度-20°C |
| 生化机理 | MF63 is a selective mPGES-1 inhibitor with an IC50 of 0.9 nM and 1.3 nM for pig mPGES-1 and human mPGES-1 enzyme, respectively. MF63 potently inhibited the human mPGES-1 enzyme with a high degree (>1000-fold) of selectivity over other prostanoid synthases. In rodent species, MF63 strongly inhibited guinea pig mPGES-1 but not the mouse or rat enzyme. When tested in the guinea pig and a knock-in (KI) mouse expressing human mPGES-1, the compound selectively suppressed the synthesis of PGE(2), but not other prostaglandins inhibitable by nonsteroidal anti-inflammatory drugs (NSAIDs), yet retained NSAID-like efficacy at inhibiting lipopolysaccharide-induced pyresis, hyperalgesia, and iodoacetate-induced osteoarthritic pain. |
| 别名 | ; |
MF63,mPGES-1抑制剂
MF63 （订货以英文为准）
编号：M127082
CAS号：892549-43-8
分子式：C23H11N4CL
分子量：378.81
| 产品名称 | MF63 |
| 中文名称 | MF63,mPGES-1抑制剂 |
| CAS号 | 892549-43-8 |
| 分子式（M.F.） | C23H11N4CL |
| 分子量（M.W.） | 378.81 |
| 储存条件 | -20°C储存 |
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