| 存贮条件 | 储存温度-20°C |
| 应用 | A potent and selective PDK-1 inhibitor that induces apoptosis |
| 产品介绍 | BX-912是一种有效的，特异性的PDK1抑制剂，IC50为12 nM，作用于PKD1比作用于PKA和PKC选择性分别高9和105倍。 |
| 备注 | BX912 is a potent and specific PDK1 inhibitor with IC50 of 12 nM, 9- and 105- fold greater selectivity for PKD1 than PKA and PKC, respectively. In comparison to GSK3β, selectivity for PDK1 is 600-fold. |
| 生化机理 | BX-912 is a PDK-1 inhibitor. BX 912 suppresses growth in a number of cell lines and also induces apoptosis. Cell lines with elevated levels of AKT are >30-fold more sensitive to PDK1 inhibition by BX-912. This compound is a competitive inhibitor of PDK1, indicating that it binds to the ATP-binding pocket to inhibit phosphorylation. BX-912 accomplishes this due to the fact that the aminopyrimidine backbone, which adopts a similar conformation to ATP in the active site of PDK1. BX-912 potently inhibits the growth of PC-3 cells in soft agar, displaying an IC50 of 320 nM. |
| 别名 | N-[3-[[5-溴-4-[[2-(1H-咪唑-5-基)乙基]氨基]-2-嘧啶基]氨基]苯基]-1-吡咯烷甲酰胺;BX912;BX 912;N-(3-(4-(2-(1H-imidazol-5-yl)ethylamino)-5-bromopyrimidin-2-ylamino)phenyl)pyrrolidine-1-carboxamide |
BX-912,PDK1 抑制剂
BX-912 （订货以英文为准）
编号：B126138
CAS号：702674-56-4
分子式：C20H23BRN8O
分子量：471.35
| 产品名称 | BX-912 |
| 中文名称 | BX-912,PDK1 抑制剂 |
| CAS号 | 702674-56-4 |
| 分子式（M.F.） | C20H23BRN8O |
| 分子量（M.W.） | 471.35 |
| 储存条件 | -20°C储存 |
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