| 沸点 | 460.41° C at 760 mmHg |
| 熔点 | 214.79° C |
| 折光率 | 1.72 |
| 溶解性 | DMSO >10 mg/mL |
| 存贮条件 | 储存温度-20°C |
| 密度 | 1.4900 |
| 应用 | A TGF-β signaling blocker |
| 产品介绍 | SD-208是口服活性的ATP竞争性TGF-βRI抑制剂，IC50为49 nM，比对TGF-βRII和其它激酶的抑制性高100倍和17倍。 |
| 生化机理 | SD-208 is a potent, orally active TGF-βR I kinase inhibitor (TGF-βRI) with IC50 =49 nM based on direct enzymatic assay of TGFRI kinase (ALK5) activity with a specificity of >100-fold against TGFRII and at least 17-fold over members of a panel of related protein kinases including p38a, p38b, p38d, JNK1, EGFR, MAPKAPK2, MKK6, ERK2, PKC, PKA, PKD, CDC2, and CaMKII. SD-208 exhibits anti-inflammatory and antitumor activity. |
| 别名 | SD 208; SD208; SCI 208; 2-(5-氯-2-氟苯基)-N-4-吡啶基-4-蝶啶胺;SD 208; SD208; SCI 208; 2-(5-Chloro-2-fluorophenyl)-N-4-pyridinyl-4-pteridinamine;2-(5-Chloro-2-fluorophenyl)pteridin-4-yl)pyridin-4-yl amine |
SD-208,ATP竞争性TGF-βRI抑制剂
SD-208 （订货以英文为准）
编号：S125587
CAS号：627536-09-8
分子式：C17H10CLFN6
分子量：352.75
| 产品名称 | SD-208 |
| 中文名称 | SD-208,ATP竞争性TGF-βRI抑制剂 |
| CAS号 | 627536-09-8 |
| MDL编码 | MFCD11519969 |
| 分子式（M.F.） | C17H10CLFN6 |
| 分子量（M.W.） | 352.75 |
| 储存条件 | -20°C储存 |
| 标识符号 | https://www.aladdin-e.com/images/ghs/ghs02.jpg,https://www.aladdin-e.com/images/ghs/ghs08.jpg,https://www.aladdin-e.com/images/ghs/ghs07.jpg |
| 信号词 | Danger |
| 危害声明 | H225,H350,H340,H304,H319,H315,H372 |
| 警示性声明 | P210,P201,P308+P313,P301+P330+P331,P305+P351+P338,P314 |
| 个人防护设备 | Faceshields,full-face respirator (US),Gloves,Goggles,multi-purpose combination respirator cartridge (US),type ABEK (EN14387) respirator filter |
| WGK德国 | 3 |
| 风险声明 (欧洲) | 45,46,11,36/38,48/23/24/25,65 |
| 安全声明（欧洲） | 53,26,36/37,45,62 |
| 危害码（欧洲） | F,T |
| 是否危化品 | 一般危化品 |
| UN代码 | 3462 |
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