货号	品牌	包装	目录价	您的价格
C126262-100mg	阿拉丁	100mg	¥9886.90	请登录
C126262-5mg	阿拉丁	5mg	¥1031.90	请登录
C126262-10mg	阿拉丁	10mg	¥1544.90	请登录
C126262-50mg	阿拉丁	50mg	¥6179.90	请登录
C126262-25mg	阿拉丁	25mg	¥3295.90	请登录

产品名称	CC-930
中文名称	CC-930
CAS号	899805-25-5
分子式（M.F.）	C21H23F3N6O2
分子量（M.W.）	448.44
储存条件	-20°C储存

溶解性	25°C: DMSO
存贮条件	储存温度-20°C
生化机理	Description:IC50 Value: 61nM (JNK1); 7nM (JNK2); 6nM (JNK3) [1]CC-930 is a selective c-Jun amino-terminal kinase (JNK) inhibitor and is currently under clinical development for fibrotic and infammatory indications.in vitro: Compound 1 (CC-930) showed remarkable selectivity in a panel of 240 kinases, EGFR being the only non-MAP kinase inhibited more than 50% at 3 lM (IC50 = 0.38 lM). It inhibited no receptor at greater than 50% at 10 lM concentration in a panel of 75 receptors, ion channels and neurotransmitter transporters. Finally, when tested against 22 diverse non-kinase enzymes at 10 lM, no inhibition greater than 50% was observed [1]. Incubation with CC-930 prevented the phosphorylation of c-Jun and reduced the stimulatory levels of these cytokines on the release of collagen [2].in vivo: Inhibition of JNK by CC-930 prevented dermal thickening, myofibroblast differentiation and the accumulation of collagen in a dose-dependent manner in mice challenged with bleomycin and in TSK1 mice. In addition to the prevention of fibrosis, treatment with pharmacologically relevant doses of CC-930 also induced regression of established experimental fibrosis [2]. CC-930 did not affect blood pressure, kidney hypertrophy, glomerular hyperfiltration, podocyte loss, glomerular fibrosis or tubulointerstitial injury in diabetic SHR (spontaneously hypertensive rats). However, CC-930 reduced macrophages and ccl2 mRNA levels in diabetic kidneys [3].Toxicity: There were no deaths or AEs that led to withdrawal during the study. Fifteen (33%) subjects reported a total of 22 treatment-emergent adverse events (TEAEs). Subject 207 (25-mg CC-930 group) was involved in a road traffic accident 6 days after the dose and was hospitalized. This adverse event was considered as a serious adverse event but not related to the study drug. The severity of all other adverse events was rated as mild [4].Clinical trial: N/A

CC-930

CC-930 （订货以英文为准）