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托伐普坦

Tolvaptan （订货以英文为准）

编号：T129870
CAS号：150683-30-0
分子式：C26H25CLN2O3
分子量：448.94
货号 品牌 包装 目录价 您的价格 库存 数量 购买
T129870-10mg 阿拉丁 10mg ¥987.90
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T129870-250mg 阿拉丁 250mg ¥9269.90
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T129870-1g 阿拉丁 1g ¥25955.90
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T129870-50mg 阿拉丁 50mg ¥3089.90
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产品名称 Tolvaptan
中文名称 托伐普坦
CAS号 150683-30-0
分子式（M.F.） C26H25CLN2O3
分子量（M.W.） 448.94
储存条件 2-8°C储存
熔点225-230 °C
溶解性Soluble in DMSO (90 mg/mL at 25 °C), water (<1 mg/mL at 25 °C), and ethanol (6 mg/mL at 25 °C).
存贮条件储存温度 2-8°C
应用A selective vasopressin receptor 2 antagonist.
产品介绍Tolvaptan是一种选择性，竞争性的精氨酸加压素受体2拮抗剂，抑制AVP-诱导的血小板聚集，IC50为1.28μM。
备注Tolvaptan is a selective, competitive arginine vasopressin receptor 2 antagonist with an IC50 of 1.28μM for the inhibition of AVP-induced platelet aggregation.
生化机理Tolvaptan is a selective, competitive AVP Receptor V2 antagonist with an IC50 of 1.28μM for the inhibition of AVP-induced platelet aggregation. Tolvaptan is used to treat hyponatremia associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone. Tolvaptan is also in fast-track clinical trials for polycystic kidney disease. Treatment with Tolvaptan causes rapid and sustained body weight reductions concurrent with increases in urine output, improves and/or normalizes serum sodium in hyponatremic patients, reduces signs and symptoms of congestion and increases thirst. However, Tolvaptan has not been shown to decrease heart failure re-hospitalization or mortality. As an adjunct to standard therapy, Tolvaptan is unique in that it is virtually the only novel agent tested in patients hospitalized for acute heart failure syndrome to reach its primary end point for short-term efficacy without causing deleterious side effects.
别名托伐普坦; N-[4-[(7-氯-5-羟基-2,3,4,5-四氢-1-苯并氮杂卓-1-甲酰基]-3-甲基苯基]-2-甲基苯甲酰胺;N-[4-[(7-Chloro-2,3,4,5-tetrahydro-5-hydroxy-1H-1-benzazepin-1-yl)carbonyl]-3-methylphenyl]-2-methylbenzamide;OPC 41061; Samsca; OPC-41061
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