概述
Fusion protein corresponding to a region derived from 805-1020 amino acids of human COVID-19 S protein
技术规格
| Full name: | COVID-19 S2 Recombinant Protein |
| Synonyms: | 2019-nCoV; SARS-CoV-2; spike glycoprotein |
| Swissprot: | P0DTC2 |
| Gene Accession: | MN908947 |
| Purity: | >85%, as determined by Coomassie blue stained SDS-PAGE |
| Expression system: | Escherichia coli |
| Tags: | His tag N-Terminus |
| Background: | Mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes. |
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