概述
Fusion protein corresponding to a region derived from 1-128 amino acids of human BEX2
技术规格
| Full name: | brain expressed X-linked 2 |
| Synonyms: | BEX1; DJ79P11.1 |
| Swissprot: | Q9BXY8 |
| Gene Accession: | BC015522 |
| Purity: | >85%, as determined by Coomassie blue stained SDS-PAGE |
| Expression system: | Escherichia coli |
| Tags: | His tag C-Terminus, GST tag N-Terminus |
| Background: | This gene belongs to the brain expressed X-linked gene family. The encoded protein interacts with the transcription factor LIM domain only 2 in a DNA-binding complex that recognizes the E-box element and promotes transcription. This gene has been found to be a tumor suppressor that is silenced in human glioma. In breast cancer cells, this gene product modulates apoptosis in response to estrogen and tamoxifen, and enhances the anti-proliferative effect of tamoxifen. Multiple transcript variants encoding different isoforms have been found for this gene. |
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