| 溶解性 | DMSO <20mg/mL; Ethanol <20mg/mL; DMF <20mg/mL |
| 存贮条件 | 储存温度-20°C |
| 产品介绍 | Salirasib是一种有效的竞争性prenylated protein methyltransferase (PPMTase)抑制剂， Ki为2.6 μM，其抑制Ras甲基化。Phase 2。 |
| 生化机理 | Salirasib is a salicylic acid derivative with potential antineoplastic activity. Salirasib dislodges all Ras isoforms from their membrane-anchoring sites, thereby preventing activation of RAS signaling cascades that mediated cell proliferation, differentiation, and senescence. RAS signaling is believed to be abnormally activated in one-third of human cancers, including cancers of the pancreas, colon, lung and breast. Salirasib binds to a cell membrane anchor protein thereby selectively blocking a cascade of biochemical signals known as the Ras signaling pathway. The Ras pathway plays an important role in tumor growth and is believed to be abnormally activated in one-third of human cancers, including cancers of the pancreas, colon, lung and breast. Up to 90% of human pancreatic cancers are driven by aberrant oncogenic Ras signaling. |
| 别名 | ;S-Farnesylthiosalicylic acid; Farnesyl Thiosalicylic Acid; FTS |
Salirasib,竞争性PPMTase抑制剂
Salirasib （订货以英文为准）
编号：S124985
CAS号：162520-00-5
分子式：C22H30O2S
分子量：358.54
| 产品名称 | Salirasib |
| 中文名称 | Salirasib,竞争性PPMTase抑制剂 |
| CAS号 | 162520-00-5 |
| 分子式（M.F.） | C22H30O2S |
| 分子量（M.W.） | 358.54 |
| 储存条件 | -20°C储存 |
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