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盐酸氨溴索

Ambroxol HCl （订货以英文为准）

编号：A129556
CAS号：23828-92-4
分子式：C13H18BR2N2O.HCL
分子量：414.56
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A129556-5g 阿拉丁 5g ¥187.90
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A129556-25g 阿拉丁 25g ¥744.90
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A129556-100g 阿拉丁 100g ¥1360.90
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A129556-1g 阿拉丁 1g ¥57.90
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产品名称 Ambroxol HCl
中文名称 盐酸氨溴索
CAS号 23828-92-4
MDL编码 MFCD00078932
分子式（M.F.） C13H18BR2N2O.HCL
分子量（M.W.） 414.56
熔点235°C(dec.)(lit.)
溶解性Soluble in methanol, water (~5 mg/ml), ethanol (~5 mg/ml), and DMSO (50 mM). Insoluble in ether.
应用An expectorant antioxidant and antiinflammatory agent
产品介绍Ambroxol HCl是有效的神经性钠离子通道抑制剂，抑制抗TTX的钠离子电流，相位性阻滞，IC50为22.5 μM，抑制对TTX敏感的钠离子电流，IC50为100 μM。Phase 3。
备注AmbroxolHCl is a potent inhibitor of the neuronal Na+ channels, inhibits TTX-resistant Na+ currents with IC50 of 35.2 μM and 22.5 μM for tonic and phasic block, inhibits TTX-sensitive Na+ currents with IC50 of 100 μM. Phase 3.
生化机理Ambroxol hydrochloride is a small molecule expectorant and mucolytic agent with antioxidant and antiinflammatory effects. Ambroxol stimulates the secretion of surfactant which decreases mucus adhesion to the bronchial lining and produces expectorant effects. The antioxidant effects of Ambroxol are well demonstrated, where lipid peroxidation initiated by t-butyl hydroperoxide or doxorubicin is suppressed in the presence Ambroxol, and scavenging of hydroxyl radicals and cellular superoxide radical anions is also observed. Ambroxol produces antiinflammatory effects by blocking the expression of proinflammatory messengers, inhibiting the release of histamine from mast cells and the generation of cytokines and interleukins. Ambroxol hydrochloride is an inhibitor of Sodium Channel Protein.
别名氨溴索 盐酸盐;2-氨基-3,5-二溴-N-(反式-4-羟基环己基)苄胺;Ambroxol Hydrochloride;trans-4-[(2-Amino-3,5-dibromobenzyl)amino]cyclohexanol Hydrochloride;2-Amino-3,5-dibromo-N-(trans-4-hydroxycyclohexyl)benzylamine
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