| 沸点 | 210 °C |
| 熔点 | -17 °C |
| 折光率 | 1.489 |
| 密度 | 0.8600 |
| 应用 | 1,4-diisopropylbenzene (DIPB) has been used in the Trivalent Actinide-Lanthanide Separation by Phosphorus reagent Extraction from Aqueous Komplexes (TALSPEAK) process for separating trivalent lanthanides from trivalent actinide cations, in used nuclear fuel reprocessing. |
| 产品介绍 | 1,4-diisopropylbenzene (DIPB) is one of the components of crude petroleum |
| 别名 | 1,4-二异丙苯; 对二异丙基苯; 对二异丙苯; |
1,4-二异丙基苯
1,4-Diisopropylbenzene （订货以英文为准）
编号：D155007
CAS号：100-18-5
分子式：C12H18
分子量：162.27
| 产品名称 | 1,4-Diisopropylbenzene |
| 中文名称 | 1,4-二异丙基苯 |
| CAS号 | 100-18-5 |
| 分子式（M.F.） | C12H18 |
| 分子量（M.W.） | 162.27 |
| 储存条件 | 充氩 |
| Reaxys-RN | 969517 |
| 危害声明 | H411 |
| 警示性声明 | P273 |
| 个人防护设备 | Eyeshields， Gloves |
| RTECS | CO4570000 |
| WGK德国 | 2 |
技术规格
| Background: | NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and RelB-p50 complexes are transcriptional activators. The NF-kappa-B p50-p50 homodimer is a transcriptional repressor, but can act as a transcriptional activator when associated with BCL3. NFKB1 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p105 and generation of p50 by a cotranslational processing. The proteasome-mediated process ensures the production of both p50 and p105 and preserves their independent function, although processing of NFKB1/p105 also appears to occur post-translationally. p50 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. In a complex with MAP3K8, NFKB1/p105 represses MAP3K8-induced MAPK signaling; active MAP3K8 is released by proteasome-dependent degradation of NFKB1/p105. |
| Applications: | WB, IHC, IF |
| Name of antibody: | NFKB1 (Phospho-Ser337) |
| Immunogen: | Synthetic peptide of human NFKB1 (Phospho-Ser337) |
| Full name: | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (Phospho-Ser337) |
| Synonyms： | p50; KBF1; p105; EBP-1; NF-kB1; NFKB-p50; NFkappaB; NF-kappaB; NFKB-p105; NF-kappa-B |
| SwissProt: | P19838 |
| IHC positive control: | Human breast carcinoma |
| IHC Recommend dilution: | 50-100 |
| WB Predicted band size: | 50 kDa; 120 kDa |
| WB Positive control: | HeLa cells |
| WB Recommended dilution: | 500-1000 |
| IF Positive control: | HeLa cells |
| IF Recommended dilution | 100-200 |
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