| 溶解性 | DMSO 82 mg/mL Water <1 mg/mL Ethanol <1 mg/mL |
| 存贮条件 | 储存温度-20°C |
| 产品介绍 | NPS-2143(SB 262470A)是选择性的Ca(2+)受体拮抗剂，IC50为43 nM。 |
| 生化机理 | NPS 2143, even when tested at much higher concentrations (3 microM), did not affect the activity of a number of other G protein-coupled receptors, including those most structurally homologous to the Ca2+ receptor. NPS 2143 stimulated parathyroid hormone (PTH) secretion from bovine parathyroid cells (EC50 of 41 nM) over a range of extracellular Ca2+ concentrations and reversed the effects of the calcimimetic compound NPS R-467 on [Ca2+]i and on secretion of PTH [1]. The first reported calcilytic compound was NPS 2143, an orally active molecule which elicits rapid, 3- to 4-fold increases in circulating levels of PTH . |
| 别名 | NPS 2143; SB 262470A; NPS2143;2-氯-6-[(2R)-3-[[1,1-二甲基-2-(2-萘基)乙基]氨基]-2-羟基丙氧基]苯腈;NPS 2143; SB 262470A; NPS2143;2-Chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropoxy]benzonitrile |
NPS-2143,钙敏感受体 (CaSR) 拮抗剂
NPS-2143 （订货以英文为准）
编号：N125903
CAS号：284035-33-2
分子式：C24H25CLN2O2
分子量：408.93
| 产品名称 | NPS-2143 |
| 中文名称 | NPS-2143,钙敏感受体 (CaSR) 拮抗剂 |
| CAS号 | 284035-33-2 |
| 分子式（M.F.） | C24H25CLN2O2 |
| 分子量（M.W.） | 408.93 |
| 储存条件 | -20°C储存 |
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