| 熔点 | 215-220 °C |
| 密度 | 2.7130 |
| 别名 | 1,2-二溴四氯乙烷;1,2-Dibromotetrachloroethane；sym-Dibromotetrachloroethane |
1,2-二溴-1,1,2,2-四氯乙烷
1,2-Dibromo-1,1,2,2-tetrachloroethane （订货以英文为准）
编号：D155305
CAS号：630-25-1
分子式：C2BR2CL4
分子量：325.64
| 产品名称 | 1,2-Dibromo-1,1,2,2-tetrachloroethane |
| 中文名称 | 1,2-二溴-1,1,2,2-四氯乙烷 |
| CAS号 | 630-25-1 |
| 分子式（M.F.） | C2BR2CL4 |
| 分子量（M.W.） | 325.64 |
| 储存条件 | 充氩 |
| Reaxys-RN | 1697117 |
技术规格
| Background: | LATS1 is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. LATS2 encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression. |
| Applications: | WB |
| Name of antibody: | LATS1/2(Phospho-Ser909/872) |
| Immunogen: | Synthetic peptide of human LATS1/2 |
| Full name: | large tumor suppressor kinase 1/2 |
| Synonyms: | wts; WARTS; KPM |
| SwissProt: | O95835/Q9NRM7 |
| WB Predicted band size: | 127/120 kDa |
| WB Positive control: | EGF treated HepG2 whole cell lysates |
| WB Recommended dilution: | 500-1000 |
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