| 溶解性 | Soluble in DMSO (42 mg/ml at 25 °C), water (<1 mg/ml at 25 °C), ethanol (<1 mg/ml at 25 °C), methanol, and DMF (~0.25 mg/ml)., |
| 存贮条件 | 储存温度-20°C |
| 应用 | An inhibitor of Flt and Flk (VEGFR) with antitumor properties |
| 产品介绍 | Axitinib is a non-selective receptor kinase inhibitor of Flt and Flk proteins. This compound also inhibits Flt-1(VEGFR-1), Flk-1(VEGFR-2), Flt-4(VEGFR-3), PDGFR-β and c-Kit(c-KIT) with IC50 of 0.1 nM, 0.2 nM, 0.1-0.3 nM, 1.6 nM and 1.7 nM, respectively. Axitinib is studied as an antitumor agent of various cell lines. Axitinib is an inhibitor of PDGFR-β. |
| 合法信息 | Sold for research purposes under agreement from Pfizer Inc. - Not for human or veterinary use. |
| 备注 | Axitinib is a multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ and c-Kit with IC50 of 0.1 nM, 0.2 nM, 0.1-0.3 nM, 1.6 nM and 1.7 nM, respectively. |
| 生化机理 | Axitinib blocked phosphorylation of VEGFR-2 and VEGFR-3 with average IC50s of 0.2 and 0.1 to 0.3 nM. |
| 别名 | AG 013736;阿西替尼;AG-013736;N-Methyl-2-((3-((1E)-2-(pyridin-2-yl)ethenyl)-1H-indazol-6-yl)sulfanyl)benzamide; |
阿西替尼
Axitinib （订货以英文为准）
编号：A129732
CAS号：319460-85-0
分子式：C22H18N4OS
分子量：386.47
| 产品名称 | Axitinib |
| 中文名称 | 阿西替尼 |
| CAS号 | 319460-85-0 |
| MDL编码 | MFCD09837898 |
| 分子式（M.F.） | C22H18N4OS |
| 分子量（M.W.） | 386.47 |
| 储存条件 | -20°C储存 |
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