| 溶解性 | Soluble in DMSO (200 mg/mL), ethanol (very poorly ), and water (very poorly ). |
| 存贮条件 | 储存温度-20°C |
| 应用 | Directly targets wild-type and mutant c-Abl kinase domains |
| 产品介绍 | Dasatinib是一种Src/Abl抑制剂，对生型Abl和Src激酶均有抑制作用，IC50分别为0.6 nM和0.8 nM。 |
| 备注 | Dasatinib is a novel, potent and multi-targeted inhibitor that targets Abl, Src and c-Kit, with IC50 of ＜1 nM, 0.8 nM and 79 nM, respectively. |
| 生化机理 | Dasatinib is more effective than imatinib in inhibiting the proliferation of Ba/F3 cells expressing wild-type Bcr-Abl and Bcr-Abl mutants, with the exception of T315I. Dasatinib has a two-log (～325-fold) increased potency relative to imatinib. Dasatinib is a potent wild-type and mutant c-Abl inhibitor, except T315I. Dasatinib directly targets wild-type and mutant c-Abl kinase domains and inhibits autophosphorylation and substrate phosphorylation in a concentration-dependent manner. Dasatinib displays 325-fold greater potency compared with imatinib against cells expressing wild-type Bcr-Abl. Dasatinib treatment inhibits SRC signaling, decreases growth, and induces cell cycle arrest and apoptosis in a subset of thyroid cancer cells. |
| 别名 | 达沙替尼; BMS 354825; N-(2-氯-6-甲基苯基)-2-[[6-[4-(2-羟乙基)哌嗪-1-基]-2-甲基嘧啶-4-基]氨基]-1,3-噻唑-5-甲酰胺;BMS-354825;Sprycel;BMS354825;BMS 354825; N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl]amino]-1,3-thiazole-5-carboxamide |
达沙替尼
Dasatinib （订货以英文为准）
编号：D125110
CAS号：302962-49-8
分子式：C22H26CLN7O2S
分子量：488.01
| 产品名称 | Dasatinib |
| 中文名称 | 达沙替尼 |
| CAS号 | 302962-49-8 |
| 分子式（M.F.） | C22H26CLN7O2S |
| 分子量（M.W.） | 488.01 |
| 储存条件 | -20°C储存;充氩 |
| 标识符号 | https://www.aladdin-e.com/images/ghs/ghs06.jpg,https://www.aladdin-e.com/images/ghs/ghs08.jpg,https://www.aladdin-e.com/images/ghs/ghs09.jpg |
| 信号词 | Danger |
| 危害声明 | H301 + H311 + H331-H315-H319-H335-H350-H360-H372-H410 |
| 警示性声明 | P201-P261-P273-P280-P301 + P310-P305 + P351 + P338 |
| 个人防护设备 | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
| RTECS | KG7537500 |
| WGK德国 | 3 |
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