5-氯-8-羟基-7-碘喹啉

5-Chloro-8-hydroxy-7-iodoquinoline (订货以英文为准)

编号:C123531
CAS号:130-26-7
分子式:C9H5CLINO
分子量:305.50
货号 品牌 包装 目录价 您的价格 库存 数量 购买
C123531-25g 阿拉丁 25g ¥308.90
C123531-10g 阿拉丁 10g ¥164.90
C123531-50g 阿拉丁 50g ¥514.90
C123531-250g 阿拉丁 250g ¥1469.90
产品名称 5-Chloro-8-hydroxy-7-iodoquinoline
中文名称 5-氯-8-羟基-7-碘喹啉
CAS号 130-26-7
MDL编码 MFCD00006787
分子式(M.F.) C9H5CLINO
分子量(M.W.) 305.50
储存条件 避光;充氩
熔点175°C
溶解性Soluble in DMSO (>25 mg/ml), boiling alcohol ((1:43)), methanol, and chloroform ((1:120)).
应用A metal chelating ligand that inhibits certain enzymes related to DNA replication.
产品介绍Clioquinol is a member of the hydroxyquinoline family which inhibits certain enzymes related to DNA replication. Clioquinol is a metal chelating ligand which displays protective effects in various neurodegenerative states as well as being a component in antifungal and antiprotozoal agents. It has been shown to modulate amyloid beta-peptide accumulation via upregulation of metalloprotease activity. When co-administered with vitamin B12, Clioquinol rescues lead-induced impairments of synaptic plasticity in an animal models. In recent animal studies Clioquinol has shown to reverse the progression of Parkinson's, Alzheimer's, and Huntington's diseases. Clioquinol has been observed to induce apoptosis in human cancer cell lines by generating free zinc in lysosomes.
别名奎諾仿;氯碘喹啉;氯碘羟喹;5-氯-7-碘-8-羟基喹啉;Clioqinol;5-Chloro-8-hydroxy-7-iodoquinoline; Iodochlorhydroxyquin;
Reaxys-RN18741230
搜索质检报告(COA)
搜索MSDS
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