西洛司特

Cilomilast (订货以英文为准)

编号:C124965
CAS号:153259-65-5
分子式:C20H25NO4
分子量:343.42
货号 品牌 包装 目录价 您的价格 库存 数量 购买
C124965-10mg 阿拉丁 10mg ¥999.90
C124965-5mg 阿拉丁 5mg ¥599.90
C124965-50mg 阿拉丁 50mg ¥3299.90
C124965-1mg 阿拉丁 1mg ¥299.90
C124965-100mg 阿拉丁 100mg ¥5299.90
产品名称 Cilomilast
中文名称 西洛司特
CAS号 153259-65-5
分子式(M.F.) C20H25NO4
分子量(M.W.) 343.42
储存条件 -20°C储存
溶解性DMSO 69 mg/mL Water <1 mg/mL Ethanol 50 mg/mL
存贮条件储存温度-20°C
备注Cilomilast is a potent PDE4 inhibitor with IC50 of about 110 nM, has anti-inflammatory activity and low central nervous system activity.
生化机理Cilomilast(Ariflo, SB-207499) is among the first of a new generation of PDE4 inhibitors (Ki ≈100 nM). Cilomilast (SB-207499) inhibits HPDE4 and LPDE4 catalytic activity with equal potency (Ki ≈100 nM). SB-207499 and rolipram are equipotent against LPDE4, but Cilomilast (Ariflo, SB-207499) is 100-fold less potent against HPDE4. This profile suggests that Cilomilast (Ariflo, SB-207499) retain the anti-inflammatory activity of rolipram yet have a decreased tendency to produce side effects.
别名4-cyano-4-(3-(cyclopentyloxy)-4-methoxyphenyl)cyclohexanecarboxylic acid;4-cyano-4-(3-(cyclopentyloxy)-4-methoxyphenyl)cyclohexanecarboxylic acid
搜索质检报告(COA)
搜索MSDS
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