溶解性 | DMSO 69 mg/mL Water <1 mg/mL Ethanol 50 mg/mL |
存贮条件 | 储存温度-20°C |
备注 | Cilomilast is a potent PDE4 inhibitor with IC50 of about 110 nM, has anti-inflammatory activity and low central nervous system activity. |
生化机理 | Cilomilast(Ariflo, SB-207499) is among the first of a new generation of PDE4 inhibitors (Ki ≈100 nM). Cilomilast (SB-207499) inhibits HPDE4 and LPDE4 catalytic activity with equal potency (Ki ≈100 nM). SB-207499 and rolipram are equipotent against LPDE4, but Cilomilast (Ariflo, SB-207499) is 100-fold less potent against HPDE4. This profile suggests that Cilomilast (Ariflo, SB-207499) retain the anti-inflammatory activity of rolipram yet have a decreased tendency to produce side effects. |
别名 | 4-cyano-4-(3-(cyclopentyloxy)-4-methoxyphenyl)cyclohexanecarboxylic acid;4-cyano-4-(3-(cyclopentyloxy)-4-methoxyphenyl)cyclohexanecarboxylic acid |
西洛司特
Cilomilast (订货以英文为准)
编号:C124965
CAS号:153259-65-5
分子式:C20H25NO4
分子量:343.42
产品名称 | Cilomilast |
中文名称 | 西洛司特 |
CAS号 | 153259-65-5 |
分子式(M.F.) | C20H25NO4 |
分子量(M.W.) | 343.42 |
储存条件 | -20°C储存 |
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