| 溶解性 | DMSO 25 mg/mL Water <1 mg/mL Ethanol <1 mg/mL |
| 存贮条件 | 储存温度-20°C |
| 备注 | AT13387 is a selective potent Hsp90 inhibitor with IC50 of 18 nM in A375 cells, displays a long duration of anti-tumor activity. |
| 生化机理 | AT13387 is a synthetic, orally bioavailable, small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity. Hsp90 inhibitor AT13387 selectively binds to Hsp90, thereby inhibiting its chaperone function and promoting the degradation of oncogenic signaling proteins involved in tumor cell proliferation and survival. Hsp90, a chaperone protein upregulated in a variety of tumor cells, regulates the folding, stability and degradation of many oncogenic signaling proteins. AT13387 is a selective potent heat shock protein 90 (Hsp90) inhibitor with IC50 of 18 nM in A375 cells. The Kd for AT13387 binding is 0.7 nM. |
| 别名 | (2,4-dihydroxy-5-isopropylphenyl)(5-((4-methylpiperazin-1-yl)methyl)isoindolin-2-yl)methanone;(2,4-dihydroxy-5-isopropylphenyl)(5-((4-methylpiperazin-1-yl)methyl)isoindolin-2-yl)methanone |
AT13387,Hsp90抑制剂
AT13387 （订货以英文为准）
编号：A127900
CAS号：912999-49-6
分子式：C24H31N3O3
分子量：409.52
| 产品名称 | AT13387 |
| 中文名称 | AT13387,Hsp90抑制剂 |
| CAS号 | 912999-49-6 |
| 分子式（M.F.） | C24H31N3O3 |
| 分子量（M.W.） | 409.52 |
| 储存条件 | -20°C储存 |
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