| 沸点 | ~646.9° C at 760 mmHg |
| 熔点 | 246.28° C |
| 折光率 | 1.73 |
| 溶解性 | DMSO 3 mg/mL Water <1 mg/mL Ethanol <1 mg/mL |
| 存贮条件 | 储存温度-20°C |
| 密度 | 1.4000 |
| 应用 | A DNA-PK inhibitor, and antitumor agent in vitro. |
| 产品介绍 | KU-57788(NU7441)是DNA-PK选择性抑制剂，IC50为14 nM，对mTOR，PI3K，ATM和ATR的抑制性较弱。 |
| 生化机理 | NU7441 increased the cytotoxicity of ionizing radiation and etoposide in SW620, LoVo, and V3-YAC cells but not in V3 cells, confirming that potentiation was due to DNA-PK inhibition. NU7441 substantially retarded the repair of ionizing radiation-induced and etoposide-induced DSB. NU7441 appreciably increased G(2)-M accumulation induced by ionizing radiation, etoposide, and doxorubicin in both SW620 and LoVo cells . |
| 别名 | KU 57788; NU-7441; KU57788; NU7441; NU 7441;8-(4-二苯并噻吩基)-2-(4-吗啉基)-4H-1-苯并吡喃-4-酮;KU 57788; NU-7441;KU57788;NU7441;NU 7441;8-(4-Dibenzothienyl)-2-(4-morpholinyl)-4H-1-benzopyran-4-one |
NU7441(KU-57788),DNA-PK抑制剂
NU7441 (KU-57788) （订货以英文为准）
编号：K126842
CAS号：503468-95-9
分子式：C25H19NO3S
分子量：413.49
| 产品名称 | NU7441 (KU-57788) |
| 中文名称 | NU7441(KU-57788),DNA-PK抑制剂 |
| CAS号 | 503468-95-9 |
| 分子式（M.F.） | C25H19NO3S |
| 分子量（M.W.） | 413.49 |
| 储存条件 | -20°C储存 |
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